Microcore is Research & Development based Biotech company that focused on the discovery, development, and manufacturing of clinically validated specialty nutraceuticals. Microcore's commitment to addressing chronic conditions indicates a potential contribution to improving the quality of life for individuals dealing with such health challenges. It's also notable that the company has evolved from a research-oriented entity to a fully-integrated, innovation-led global enterprise, suggesting a comprehensive approach to product development and manufacturing. Microcore specializes in the development of nutraceuticals targeting a range of chronic conditions, including Arthritis, Osteoarthritis, Osteoporosis, Osteopenia, Inflammatory diseases, Rheumatoid arthritis, as well as products related to Hair and skin care.
It is a great honor to be ranked and chosen amongst an overwhelming number of 37134 nominations filed by SMEs from all over the country and we are delighted to share our happiness with you that MICROCORE is a winner of INDIA SME TOP 100 award 2022
Unit-1 R&D infrastructure, Process development and Production facilities are located at Erode the Textile and Turmeric City of South India.(15,000 sqf ) & Unit-2 Asia's largest Egg Shell Membrane processing is under expansion at Tiruchirappalli to Karur at (20 Acres).
Microcore's in-house Research and Development efforts have been recognized by the Department of Scientific and Industrial Research (DSIR) of the Government of India. A cumulative experience of 25 years in research, operation, and manufacturing is indeed a significant accomplishment and a testament to Microcore's commitment to innovation and scientific advancements.
The fact that Microcore is the
only company holding PA-II approval for Egg Membrane-based
product ranges is a notable achievement. This approval
likely signifies that Microcore's products have undergone
rigorous testing and evaluation, meeting the necessary
standards set by regulatory authorities.
No.01/std/PA/FSSAI/2021
No.02/std/PA/FSSAI/2021
No.02/std/PA/FSSAI/2021 (Part 1)
No.60/std/PA/FSSAI/2022
1.Health Claim :- Microcore Natural Egg Shell Membrane promoting the healthy maintenance of joints and connective tissues.
2.Health Claim :- Microcore Natural Egg shell Calcium preventing the risk of Osteoporosis.
It's highlight the potential benefits of Microcore's offerings It's clear that Microcore's extensive experience has played a crucial role in developing scientific innovations and successfully scaling them up to industrial levels. This kind of expertise and recognition can contribute significantly to the growth and credibility of the company in the scientific and industrial sectors. The approval and sanctioning of the Nutraceutical Egg membrane formulation through Form II application! This achievement, combined with Trade Mark registration, granted patents for both the process and the product, and exclusive Clinical Trials Registry-India (CTRI) registered clinical studies, reflects a comprehensive and well-documented approach to the development of your nutraceutical product. Moreover, the fact that these nutraceuticals are produced in a facility certified under Good Manufacturing Practices (GMP), ISO-22000, and are Halal certified is significant. Adhering to these quality standards ensures the safety, efficacy, and quality of the products, which is crucial in the nutraceutical industry.
Our commitment to manufacturing and supplying clinically validated nutraceutical ingredients and blends adds another layer of credibility to your offerings. This could be particularly appealing to consumers, healthcare professionals, and other stakeholders who prioritize evidence-based and clinically tested products.These certifications and validations provide a solid foundation for establishing trust in the market and differentiating your products from others. It's evident that Microcore has made substantial investments in ensuring the highest standards in the development, production, and supply of its nutraceuticals.
Microcore's achievements and its unique position in the market with intellectual property rights for Natural Egg Shell Membrane and Un-denatured Collagen Type-II. Obtaining the functional health claim from CENTRAL/FSSAI/STD/DELHI is a significant milestone that adds credibility to the company's products. . These claims can be valuable in marketing and positioning the products in the health and wellness sector. The focus on selling branded bio-actives as ingredients, blends, and finished products under names like MUTTAIJOW COMPLEX® , MUTTAI ODUJOW® , AKBACORE® , and CUMINCORE® demonstrates a strategic approach to branding and product differentiation. The fact that Microcore has conducted comparative clinical studies of Egg Shell Membrane-based nutraceutical combinations versus Diacerin-based drug combinations in knee osteoarthritis patients is commendable. Such scientific validation and research contribute to the credibility of the products and can play a crucial role in gaining trust among consumers and healthcare professionals.As a pioneer in these areas, Microcore seems well-positioned to make significant contributions to the field of health and wellness, especially in joint health and osteoporosis prevention. Continued innovation, research, and a commitment to high-quality standards will likely contribute to the company's success in the market.
Benefits if Microcore's UD-Core-II®
UDCORE-ii, which is Microcore's Undenatured Chicken Sternum Collagen Complex II. This product is derived from chicken sternum through a backward integration process and is produced using various certifications such as ISO-22000, GMP, FSSAI/CL, HALAL, and Kosher. The key feature of UDCORE-ii ®is its integrated epitope or antigencity. Undenatured Collagen Type-II has a specific mechanism of action. It is designed to be taken up by Dendritic cells (DCs) in the Gut-Associated Lymphoid Tissue (GALT) in its glycosylated form. This process allows T helper cells to recognize the antigen epitopes, leading to an initial mild immune response. Over time, this can contribute to the development of oral tolerance, which means the immune response against cartilage collagen II is attenuated. The gradual development of oral tolerance is crucial in suppressing the immune response against collagen II. This stimulation of T regulatory cells and suppression of T helper cell response can ultimately lead to the effective suppression of inflammatory cartilage collagen destruction. As a result, the synthesis of endogenous collagen or supplementation with collagen peptides becomes more effective once the immune response is adequately suppressed.The use of patent-granted technologies in the production of UDCORE-ii adds to its uniqueness and potentially enhances its effectiveness in promoting oral tolerance and addressing issues related to cartilage collagen destruction. It's worth noting that this information is specific to the details you provided and may be subject to further scientific research and development..
Significances of Clinical Studies by Microcore
Clinical studies CTRI/2021/08/035335 conducted by MICROCORE consolidated NESM formula for many health benefits. Microcore's NESM (MUTTAIJOW COMPLEX® | MUTTAI ODUJOW®) is a health supplement designed to support joint and connective tissue health. Here are some key points based on the information provided:
Composition: The product is described as a complex protein molecule containing a natural composition of various elements, including collagen (types I, III, V, X), elastin, chondroitin sulfate, glucosamino glycan, hyaluronic acid, and fractional active bio-peptides.
Chemical-free Manufacturing: Microcore NESM is claimed to be manufactured without the use of any chemicals and solvents, emphasizing its natural and chemical-free nature.
Nutrient Powerhouse: The product is positioned as a nutrient powerhouse with a variety of glycosaminoglycans, dermatan sulfate, keratan sulfate, and other active components, which can contribute to joint health.
pH Range: The supplement is stated to be available within a pH range of 7.5 to 9, suggesting an alkaline nature. Alkaline foods are often associated with potential health benefits.
Health Benefits: Microcore NESM is suggested to have a positive impact on maintaining healthy joints and connective tissues, particularly in patients with osteoarthritis (OA). The term "Nutraceuticals" indicates that it serves both nutritional and pharmaceutical roles.
Certifications: The product has obtained certifications such as ISO-22000, GMP (Good Manufacturing Practice), FSSAI/CL (Food Safety and Standards Authority of India/Central License), HALAL, Kosher, and holds Patent Granted Technologies. FSSAI Approval: Microcore NESM is mentioned to be approved by the Food Safety and Standards Authority of India (FSSAI) under the 13.6 category with reference to FSSAI/STD/Delhi.
Reference :- A randomized, open‑label, multicentered parallel‑group clinical study to evaluate the efficacy and safety of Joint Core® compared to Jointace DN in osteoarthritis patients 2022 Journal of Current Research in Scientific Medicine | Published by Wolters Kluwer Medknow jcrsm_21_22_R2_OA 10.4103/jcrsm.jcrsm_21_22 JOURNAL- DOWNLOAD
Results
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Joint Core® and its potential benefits for managing Osteoarthritis. Here's a summary of the key points:
1.Creatinine Reduction :- Joint Core® is claimed to reduce Sr creatinine values by 25% from 1.1 (+/-) 1.0 at zero day to 0.83 (+/-) 0.19 in 12 weeks.
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2.Anti-inflammatory Activity:- It is suggested that Joint Core® has anti-inflammatory activity, as evidenced by the control of HS-CRP inflammatory markers from 7.15 (+/-) 4.6 to 3.86 (+/-) 2.91 and ESR inflammatory markers from 45.75 (+/-) 32.83 to 9.0 (+/-) 4.5 in 12 weeks.
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3.Fibrinogen Levels:- Joint Core® is claimed to reduce inflammatory markers, specifically Fibrinogen Levels, from 309.29 (+/-) 96.31 to 9.0 (+/-) 4.5 in 12 weeks.
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4.Improvement in Osteoarthritis Patients: Joint Core® is said to show significant improvement in Osteoarthritis patients, addressing pain, reducing inflammatory markers, and improving functional capacity.
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5.Natural Supplement:- The product is described as a natural supplement containing Natural eggshell membrane (MuttaiJowComplex®), ABKACORE® (Boswellia serrata), and CUMINCORE® (Curcumin extract96%).
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6.Pain Management: Joint Core® is claimed to provide better and early pain management, as per comparative data on PAIN VAS SCALE, WOMAC PAIN SUB SCALE, GLOBAL ASSESSMENT ON IMPROVEMENTS ON OSTEOARTHRITIS SCORE, OMERACT-OARSI.
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7.Equivalent to Reference Drug:- Joint Core® is suggested to be equivalent to the reference drug combination Jointace DN in managing Osteoarthritis, reducing inflammation, providing pain relief, and improving functional capacity, without major side effects or drug interactions.
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8.NF-kB Activation:-The product claims to activate the level of nuclear factor kappa-light-chain-enhancer of activated B cells ("NF-kB") in the gut, helping in NF-kB dys-regulations.
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9.Reduction of Pro-inflammatory Cytokines: Joint Core® is claimed to reduce early-phase pro-inflammatory cytokines like IL-6, IL-10, and TNF-α,β involved in later phases of the inflammatory process.
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10.Treatment of Pain and Stiffness: The product is stated to help in the treatment of pain and stiffness associated with the knee. Targeting Root Cause: Joint Core® is said to work on the root cause of arthritis.
It's important to note that while these points provide information about the product, individual results may vary, and it's advisable to consult with a healthcare professional before starting any new supplement or treatment. Additionally, the information provided here is based on the text you provided and may not be independently verified.
Branded Bioactives of Microcore
Microcore has two ranges of branded Natural Egg Shell membrane that includes Muttaijow Complex® and Muttaiodujow ®which are clinically studied. The clinical studies conducted by Microcore entitled as Randomized, open label, multicenter parallel group clinical study to evaluate the efficacy and safety of Joint Core ® in osteoarthritis patients confirms he advantages of Joint Core®.