clinically Validated Natural Egg Shell Membrane  for osteoarthritis, hair, skin, nail & eye care

B2B-Branded Bioactives

 

Muttaijow complex® is branded Natural Egg Shell Membrane produced by Microcore  from FSSAI/INDIA/CL Approved facilities.  It is a Nutraceutical supplement produced from egg albumin by highly innovative and patented technologies.  Muttaijow complex®  is free from insecticides, pesticides and chemical residues.  The patented technologies enables to produce pure ingredient that contains no  artificial additives, no preservatives and no pesticides or chemicals residues of any kind. Complete QA test is being carried right from the crude raw material and at each and every stage of the refining process to ensure residue free products for the complete integration of all active molecules. Microcore holds the  intellectual property rights for the production of NESM and the facility is of State of Art in the country. If you are looking for natural joint health  support, then it is right choice that Natural Eggshell Membrane is the best product to support the bone and connective tissues.

 

Muttaiodu Jow® is a novel dietary supplement processed from  crude Egg Shell Membrane by unique and highly innovative separation technologies, the product is free from insecticides, pesticides and chemical residues. It contain 65% egg membrane and 30 %  Shell Calcium carbonate (bio-calcium) with 96% total protein and 27 % of Elastin accounting for the elasticity of the  membrane. It contains naturally occurring Collagen Type- I,III,V,X Elastin, Chondroitin Sulfate (20%), Glycosaminoglycans (20%), Membranous protein, Hyaluronic acid etc and other fractional molecules that includes, Growth factor β, Ovocalixin, Ovocleidin, Ovotransferrin, Desmosine, Isodesmosine and Sulphur-bearing amino acids as essential to maintaining healthy joint and connective tissues. 

 

Significances of Clinical Studies by Microcore

 

Clinical studies CTRI/2021/08/035335 & CTRI /2023/02/049901 conducted by  MICROCORE  consolidated  Egg Membrane and Egg Calcium formula for many health benefits. 

 

Microcore is the first company that has successfuly completed clinical studies to prove that Natural Egg Shell Membrane based Nutraceuticals combinations are equivalent or better than Diacerin based drug Combinations, for more details pl refer | http://jointcore.us/

 

* Reference :- A randomized, open‑label, multicentered parallel‑group clinical study to evaluate the efficacy and safety of Joint Core® compared to Jointace DN  in osteoarthritis patients  2022 Journal of Current Research in Scientific Medicine | Published by Wolters Kluwer  Medknow jcrsm_21_22_R2_OA 10.4103/jcrsm.jcrsm_21_22  JOURNAL- DOWNLOAD

 

* Reference :-  A RANDOMIZED, OPEN LABEL, MULTICENTER PARALLEL GROUP CLINICAL STUDY COMPARING THE RELATIVE BIOAVAILABILITY, SAFETY AND EFFICACY OF MICROCORE NESC® WITH CALCIUM CARBONATE AND CALCIUM CITRATE MALATE IN OSTEOPENIC AND OSTEOPOROTIC PATIENTS Indian Journal of Orthopaedics Received: 29 November 2023 / Accepted: 30 January 2024 Indian Orthopaedics Association 2024 www.eggcalcium.com | https://link.springer.com/article/10.1007/s43465-024-01117-3

 

Results

  • Joint Core®  www.jointcore.us its potential benefits for managing Osteoarthritis.
         1.Creatinine Reduction :-  Claimed to reduce Sr Creatinine values by 25% from 1.1 (+/-) 1.0 at zero day to 0.83 (+/-) 0.19 in 12 weeks.

  • 2.Anti-inflammatory Activity:- Claimed that it has anti-inflammatory activity, as evidenced by the control of HS-CRP inflammatory markers from 7.15 (+/-) 4.6 to 3.86 (+/-) 2.91 and ESR inflammatory markers from 45.75 (+/-) 32.83 to 9.0 (+/-) 4.5 in 12 weeks.

  • 3.Fibrinogen Levels:-  Claimed to reduce inflammatory markers, specifically Fibrinogen Levels, from 309.29 (+/-) 96.31 to 9.0 (+/-) 4.5 in 12 weeks.

  • 4.Improvement in Osteoarthritis Patients: Show significant improvement in Osteoarthritis patients, addressing pain, reducing inflammatory markers, and improving functional capacity.

  • 5.Natural Supplement:-  The product is described as a natural supplement containing Natural eggshell membrane (MuttaiJowComplex®), ABKACORE® (Boswellia serrata) & CUMINCORE® (Curcumin extract96%).

  • 6.Pain Management: It is claimed to provide better and early pain management, as per comparative data on PAIN VAS SCALE, WOMAC PAIN SUB SCALE, GLOBAL ASSESSMENT ON IMPROVEMENTS ON OSTEOARTHRITIS SCORE, OMERACT-OARSI.

  • 7.Equivalent to Reference Drug:- It is suggested to be equivalent to the reference drug combination Jointace DN in managing Osteoarthritis, reducing inflammation, providing pain relief, and improving functional capacity, without major side effects or drug interactions.

  • 8.NF-kB Activation:-The product claims to activate the level of nuclear factor kappa-light-chain-enhancer of activated B cells ("NF-kB") in the gut, helping in NF-kB dys-regulations.

  • 9.Reduction of Pro-inflammatory Cytokines: It is claimed to reduce early-phase pro-inflammatory cytokines like IL-6, IL-10, and TNF-α,β involved in later phases of the inflammatory process.

 

Clinical significanes of Muttaijow Complex®


(1) Activating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) in the gut may contribute to the dysregulation of NF-kB.
(2) The intervention appears to have anti-inflammatory effects by reducing early-phase pro-inflammatory cytokines such as IL-1β and TNF-α, as well as other cytokines involved in later phases of inflammation.
(3) It helps control liver enzymes, specifically maintaining normal ranges of alanine transaminase (ALT) and aspartate transaminase (AST).
(4) It is beneficial for treating non-diseased individuals experiencing joint stiffness and discomfort.
(5) It aids in the treatment of individuals suffering from fibromyalgia.
(6) Eggshell membrane supplementation has shown positive effects, including reducing exercise-induced joint pain and stiffness and lowering urinary excretion of C-terminal cross-linked telopeptide of type-II collagen (uCTX-II), a marker of cartilage degradation, in healthy, postmenopausal women.
(7) It is effective in the treatment of pain and stiffness associated with the knee.
(8) It improves the appearance of facial skin and hair, reducing hair fall and damage.
(9) It suppresses the activity of pro-inflammatory cytokines, TNF-α, and IFN-γ.
(10) It leads to reduced levels of IL-6 and IL-10.
(11) It addresses the root cause of arthritis.
 

How Muttaijow Complex® is different from other's Egg Shell Membrane?


 (a) The claim that Muttaijow Complex® is made by a natural process, free from insecticides, pesticides, and chemical residues, justifying it as a Natural Egg Shell Membrane is a positive attribute. This can be appealing to consumers seeking natural and chemical-free products.
(b) The maintenance of molecular mass and structure in Muttaijow Complex® is essential for preserving the natural integrity of the epitope. This could contribute to the effectiveness of the product in providing joint and connective tissue support.
(c) Checking the pH, chlorine, H2O2, benzoyl peroxide, nitrate, acids, enzymes, and other chemical residues in egg membranes from other manufacturers is a logical step to demonstrate the advantages of Muttaijow Complex®. It implies that Muttaijow Complex® undergoes a thorough quality assessment.
(d) Comparing the detailed nutrient profiles of Muttaijow Complex® with other products across 33 parameters is a comprehensive approach. It provides a basis for consumers to make informed decisions about the nutritional content and potential benefits of the product.
(e) Clinical comparisons with Diacerin-based combinations, proving Muttaijow Complex® to be equivalent or better in terms of pain management, is a strong selling point. The mention that other manufacturers tested their egg membrane on placebo suggests a superiority claim for Muttaijow Complex®.
(f) Distinguishing between Muttaijow Complex® for joints and connective tissues and Muttaiodujow® for bone and joint formula helps consumers understand the specific focus of each product. It caters to different needs within the joint and bone health category.
(g) Highlighting the enhanced porosity suitable for nano binding in Muttaijow Complex® is a unique feature. The claim that it helps in sustainable releases in the human system and is comparable to Diacerin, with early pain management effects, positions the product as technologically advanced.
In summary, the information provided emphasizes the natural, scientific, and clinical aspects of Muttaijow Complex®, making it a compelling product in the joint and bone health market.


 Soluble Egg Shell Membrane (SESM)
Nano-soluble ESM produced by unique process technologies to produce high pure soluble egg shell membrane with 98 % protein, 40 % elastin and 27 % Collagen Type-1,V,X an 25 %. We target the development for the cosmetics applications and further pre clinical trials are under progress.
Soluble Elastin Concentrate (SEC)
Unique process technologies to produce high pure soluble elastin concentrate. We target the development for the osteoporosis, applications and further pre clinical trials are under progress.

Collagen Type - I,III,V,X & Elastin   Concentrate
Unique process technologies to produce high pure Collagen Type-I,III,V,X concentrate. We target the development for the chronic ulcers, applications and further pre clinical trials are under progress.

 

Frequently Ask Questions

 

  • What are the fractions of Natural Egg Shell Membrane?

     v CollagenType I (works on Skin, Bone, Ligaments, Connective tissues, Vascular Ligature)
     v CollagenType  III ( works on Reticular fibre)
     v Collagen Type V ( works on Placenta & Hair)
     v Collagen Type X ( works on Articular cartilages)
     v Elastin ( Complex of Desmosine and isodesmosine that works on lubrication and elasticity)
     v Hyaluronic acid ( works on elasticity)
     v Glucosamine ( works to strength the Cartilage)
     v Chondroitin ( works  to strengthen the Cartilage)
     v Glycosaminoglycans or Muco-polysaccharides. (Works to strengthen the Ligaments)
     v Membrane bound protein molecules (works on connective tissues)
     v Calcium ( works in bone mineral density)

    Rich in various components beneficial for joint and connective tissue health. Let's break down the key points:
     (a) Nutrient Powerhouse Ingredients:

    Collagen (I, III, V, X): Various types of collagen are essential proteins for the structure and function of connective tissues.
     Elastin: Another protein contributing to the elasticity of connective tissues.
     Chondroitin sulfate: A major component of cartilage that may help maintain joint health.
    Glycosaminoglycans (mucopolysaccharides): Important molecules for connective tissue support.
    Hyaluronic acid: A substance that helps retain water and keeps tissues lubricated.
    Bio-peptides: Fractional active components with potential health benefits.
    Glucosamine: A compound important for maintaining the integrity of cartilage.
    Dermatan, Keratan sulfate: Substances found in connective tissues.
    Membranous protein: Proteins associated with cell membranes.
    Growth factor β: A protein involved in cell growth and differentiation.
    Ovocalixin, Ovocleidin, Ovotransferrin: Bioactive components found in eggs.
    Desmosine, Isodesmosine: Cross-linking amino acids important for elastin stability.
    Sulphur-bearing amino acids: Essential for the synthesis of various proteins, including those in connective tissues.
     (b) Alkaline pH Range: The pH range of 8 to 9 suggests that this substance is alkaline. Alkaline foods are often associated with supporting a healthy system, as they may help balance the body's pH and create an environment less conducive to inflammation.
    (c) Biogenic Precursor for Cartilage Repair: The mention of being a biogenic precursor implies that this substance may serve as a source of building blocks for the repair of damaged cartilage. This is particularly important for individuals dealing with joint issues or injuries works as  comprehensive mixture of nutrients and bioactive components that could potentially support joint and connective tissue health, and its alkaline nature may offer additional health benefits. However, it's essential to note that specific scientific studies and clinical evidence would be necessary to validate these claims and understand the effectiveness of such a product.

  • What are the rolls of Natural Egg Shell Membrane as fibrous protein on Osteoarthritis?

    Fibrous proteins are critical to cartilage, connective tissue, skin health and gives cartilage its strength and elasticity.
    Fibrous Protein of Natural Egg Shell Membrane are  critical to skin, cardiovascular, cartilage, and spinal column health and  the elastic tension to the tissue and the ability to resume its shape after stretching.
    vital structural components of connective tissue, interstitial fluids and skeletal structures.
    Growth factor β, Ovocalixin, Ovocleidin, Ovotransferrin, Desmosine, Isodesmosine and Sulphur-bearing amino acids as essential to maintaining healthy joint and connective tissues.
    Small, peptides that are responsible for elastin elastic or rubbery properties.

  • What are the merrits of Natural Egg Shell Membrane  ?
     

    * Promotes Skin Collagen Renewal & Repair.
    * Alkaline food helps for buffering the pH & escape acid reflux.
    * Promotes Fibroblast Activity for Skin Elasticity.
    * Natural Ways of Providing Soothing Properties to Joints.
    * Supports the Skin and Body, while Encouraging Soothing Properties.
    * Helps to reduce joint pain and reduce stiffness.
    * Improve joint mobility, flexibility and function.
    * Provide joints with the building blocks needed to build cartilage for normal joint function.
    * Helps to relieve pain associated with osteoarthritis of the knee.
    * Natural alternative to non-steroidal anti-inflammatory drugs (NSAIDs) and Diacerin based drugs.
    *Contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joint  and connective tissues.

  • Is Natural Egg Shell Membrane is approved in India ?
     

    Humbly Microcore is the first research based Nutraceutical Biotech company to receive the Approval for the production Natural Egg Shell Membrane  from   FSSAI/STD/PA-II/INDIA, perhaps NESM has the global approval that includes USFDA as Self affirmed as GRAS and EU approval. Microcore has Received functional claims from FSSAI/CL/DELHI for  Natural Egg Shell Membrane  "For maintaining healthy Joints and connective Tissues"

 

  • Is the  Premix / Tablet /Capsule of  Jointcore® is Available for B2B marketing  ?
     

    Yes available at MOQ  of One lace Tablets or 100 Kg Premix.

 

What are the Clinical Significance of  Jointcore®?

 

                                                                   

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